主讲课程

《分子生物学》、《微生物生态学》

个人简介

徐安明，2020年7月于中国科学院微生物研究所获得理学博士学位。主要从事细菌生物被膜工程化应用相关的研究。基于对细菌生物被膜的形成与瓦解机制的认识，构建智能化生物被膜底盘细胞，应用于工业发酵、生物催化、生物活体功能材料等领域。相关成果发表在ISME J, Environ Microbiol, iScience, ACS Synth Biol, Appl Environ Microb, Trends in Microbiol等杂志。主持国家自然科学基金青年基金、国家重点研发计划子课题，博士后基金等项目。

学习及工作经历:

2010.09-2014.07，安徽大学，生命科学学院，生物科学，学士

2014.09-2020.07，中国科学院微生物研究所，微生物学，博士

2020.07-2022.09，999全讯白菜网，全讯白菜策略，博士后

2022.11-至今，999全讯白菜网，全讯白菜策略，副教授

代表性成果

1. Xu AM, Wang D, Wang YH, Zhang L, Xie ZS, Cui YF, Bhamse P, Yu HY, Zhang XX, Li DF, Ma LY*. (2022) Mutations in surface-sensing receptor WspA lock the Wsp signal transduction system into a constitutively active state. Environmental Microbiology 24:1150-1165.

2. Xu AM*, Daniel J. Wozniak*, Zhou J, Jiang Min, Dong WL*. (2022) Toward a unified nomenclature for strains with hyper-biofilm phonotypes. Trends in Microbiology 30(11):1019-1021.

3. Xu AM, Zhang XX, Cao SX, Zhou XL, Yu ZY, Qian XJ, Zhou J*, Dong WL*, Jiang M*. (2022) Transcription-associated fluorescence-activated droplet sorting for di-rhamnolipid hyperproducers. ACS Synthetic Biology 11:1992-2000.

4. Xu AM^#, Liu JW^#, Cao SX, Xu B, Guo CZ, Yu ZY, Chen XQ, Zhou J*, Jiang M, Dong WL*. (2022) Application of a novel fluorogenic polyurethane analogue probe in polyester-degrading microorganisms screening by microfluidic droplet. Microbial Biotechnology 16, 474-480.

5. Liu SX^#, Xu AM^#, Xie B, Xin FX, Dong WL, Zhou J*, Jiang M. (2022) Priority changes between the synthesis of biofilm exopolysaccharides and rhamnolipids are mediated by a cyclic di-GMP-specific phosphodiesterase NbdA in Pseudomonas aeruginosa. iScience, 25(12): 105531.

6. Xu AM, Zhang MK, Du WL, Wang D, Ma LY*. (2021) A molecular mechanism for how sigma factor AlgT and transcriptional regulator AmrZ inhibit twitching motility in Pseudomonas aeruginosa. Environmental Microbiology 23:572-587.

7. Xu AM, Zhang XX, Wang T, Xin FX, Ma LZ, Zhou J*, Dong WL*, Jiang M. (2021) Rugose small colony variant and its hyper-biofilm in Pseudomonas aeruginosa: Adaption, evolution, and biotechnological potential. Biotechnology Advances 53:107862.

9. Wei Q, Leclercq S, Bhasme P, Xu AM, Zhu B, Zhang YH, Zhang MK, Wang SW, Ma LY*. (2019). Diguanylate cyclases and phosphodiesterases required for basal-Level c-di-GMP in Pseudomonas aeruginosa as revealed by systematic phylogenetic and transcriptomic analyses. Applied and Environmental Microbiology 85:e01194-19.

10. Wang D, Xu AM, Elmerich C, Ma LY*. (2017) Biofilm formation enables free-living nitrogen-fixing rhizobacteria to fix nitrogen under aerobic conditions. ISME Journal 11:1602-1613.